SLC5A2 and fatty liver disease: Considered from previous papers reporting the effects of SGLT2 inhibitors on HFD-fed mice, the effects of SGLT2 inhibitors on body weight and adiposity vary across the studies; treatment with tofogliflozin suppressed HFD-induced body weight gain as well as the progression of hepatic steatosis, when it is administered for 20 weeks beginning at the start of HFD feeding22.