Not only did Arl4d−/− T cells contribute to a larger extent to the circulating T cell pool during adenovirus infection, also 8 days after adenoviral infection, the Arl4d-deficient T cells expanded significantly more than their co-transferred wild type counterparts within the spleen and the primary infection site, i.e. the liver (Fig. 4E). Here, ARL4D is linked to adenoviridae infectious disease.