The De-Ritis ratio that defined the ration between ASAT and alanine aminotransferase (ALAT) activity as a marker for hepatocellular injury was significantly enhanced in mPGES-1-deficient mice compared to wild type-mice fed a NASH-diet (2.98 ± 0.29 versus 2.08 ± 0.17) indicating that mPGES-1-deficient mice suffered from more severe hepatocyte damage. This evidence concerns the gene PTGES and metabolic dysfunction-associated steatohepatitis.