Continuous exposure of male mice to HFD caused also perturbations in glycemic homeostasis, characteristic of MetS, which were documented by a significant worsening of glucose tolerance, as revealed by GTT (p = 0.026) (Fig. 5a,b), and a (moderate) decrease in insulin sensitivity in ITT (Fig. 5c), compared to CD mice. The gene discussed is INS; the disease is metabolic syndrome.