In addition, HFD mice displayed elevated basal glucose (200.74 ± 8.9 mg/dl vs. 153.3 ± 4.73, N = 20/group – measured before initiation of the pharmacological intervention; p = 0.012) and insulin levels (p = 0.028; Fig. 5d), as evidence for a state of insulin resistance. Here, INS is linked to Insulin resistance.