BT-28 cells are derived from medulloblastoma patient with nodal dysmoplasia and >200 deleterious mutations including mutS homolog 6 (MSH6) and mutL homolog 1 (MLH1); while BT-50 is derived from SHH medulloblastoma with mutations in genes including suppressor of fused homolog (SUFU) and F-Box and WD repeat containing 7 (FBXW7). The gene discussed is MSH6; the disease is medulloblastoma.