PRMT2 and glioblastoma: To examine whether the catalytic activity of PRMT2 is required for GBM tumorigenesis, we generated two PRMT2 catalytic inactive mutants H112Q and M115I, based on the prediction (see Supplementary Methods) of the pocket site for SAM docking on PRMT233 (Supplementary Fig. 10a) and cloned them into tetracycline-inducible expression vectors.