For example, ANGPTL1 and SPARCL1, crosstalking with ANK2, have been shown to attenuate colorectal cancer metastasis in our previous work.26, 27 Hypermutated patients with higher ANK2 expression levels had a significantly better clinical outcome (P = 0.00771, log‐rank test, Figure 3D). This evidence concerns the gene ANGPTL1 and colorectal cancer.