A well‐conceived five‐gene signature (DNAI2, EPHA5, GAS2L1, RNH1, TAGLN3) was identified that could predict prognosis of hypermutated STAD patients with high performance (C‐index: 0.84), but the robustness should be validated in another independent dataset in the future. Here, EPHA5 is linked to gastric adenocarcinoma.