IL17A and myeloid sarcoma: Furthermore, a recent study demonstrated that the EP2 receptor is overexpressed in T‐cells from MS patients, while its expression in T‐cells in healthy individuals undergoes retinoic acid‐related orphan nuclear hormone receptor C‐dependent silencing and that simulation of EP2 receptors in the MS patient T‐cells induces a pathogenic Th17 phenotype characterized by co‐expression of both IL‐17A and IFN‐γ (Kofler et al., 2014), thus providing clinical relevance of the finding on PGE2‐EP2 receptor signalling in mouse Th17 cells.