Consistent with these findings, Gao et al. found that PGE2 enhances IL‐4‐induced STAT6 activation in an EP2‐dependent manner to prompt IgE switching and that in the OVA‐induced asthma model, mice with a deficiency in EP2 receptors exhibited markedly attenuated IgE antibody responses and airway inflammation (Gao et al., 2016). This evidence concerns the gene IGHE and asthma.