Similar to IP receptor‐deficient mice, EP2 receptor‐deficient mice also show an exaggerated OVA‐induced airway inflammation accompanied by increased IL‐13 production, with higher serum IgE levels, and the administration of misoprostol during the sensitization process suppressed the production of IgE and attenuated the inflammatory response (Zasłona et al., 2014). The gene discussed is IGHE; the disease is inflammatory response.