To further investigate the role of IL-38 in NSCLC development, cell migration, invasion, apoptosis, proliferation and cancer stem cells were analysed in two human NSCLC cell lines, A549 and SK-MES-1, after the administration of various concentrations of rhIL-38 (recombinant human IL-38). The gene discussed is IL1F10; the disease is non-small cell lung carcinoma.