In gastric cancer cells, the abnormally upregulated miRNA clusters (miR-106b–93–25 and miR-222–221) promote tumour growth by targeting the Cip/Kip family members of Cdk inhibitors (p57Kip2, p21Cip1 and p27Kip1) [52]. The gene discussed is CDKN1B; the disease is gastric cancer.