TLR4 and infection: As an answer to these questions, the infection of mice deficient for Toll-like receptor 2 (TLR2), TLR4, IL-10, arachidonate 5-lipoxygenase (ALOX5), or arachidonate 15-lipoxygenase (ALOX15) with the M. tuberculosis Δnrp strain showed the same phenotype as WT mice (see Fig. S5 in the supplemental material).