APOC3 and obesity due to melanocortin 4 receptor deficiency: It can be speculated that in states of adequate insulin signaling, this SNP contributes to a healthy lipoprotein phenotype manifested by low TG and high HDL cholesterol, whereas in obesity, which is generally accompanied by insulin resistance, the SNPs became irrelevant for the regulation of APOC3 expression, and consequently, their effects on TG metabolism may have been absent.