IFNA1 and Zika virus infectious disease: Furthermore, in an attempt to better model vertical ZIKV transmission, it could be shown that crossing of female immunocompromised mice with WT males produced heterozygous, IFN competent (Ifnar+/−) fetuses, which better resembled the immune status of human fetuses, with ZIKV maternal inoculation resulting in fetal demise that was associated with ZIKV infection of the placenta and fetal brain [192].