Genetically modified mice lacking either the type I IFN receptor ifnar1 gene (Ifnar1−/−) or the transcription factors Irf3, Irf5 and Irf7 (Irf3−/−, Irf5−/−, Irf7−/− triple knockout) in 129 (A129) or C57BL/6 background have been shown to be highly susceptible to ZIKV infection and to develop severe diseases following peripheral inoculation, including development of neurological disease and death [70,175,176,180,187,188,189,190]. The gene discussed is IRF3; the disease is Zika virus infectious disease.