STAT1 and hyperinsulinemic hypoglycemia, familial, 4: There are several studies showing that infection of immunocompromised AG129 (IFN type I and II receptors deficiency), A129 (IFN type I receptor deficiency) or Stat1−/− mice with ZIKV and subsequent treatment with potential antiviral compounds can lead to decreased viral burden in various tissues, reduced pathology, as well as reduced or delayed morbidity and mortality [156,193,198,199,200,201,202,203].