A common pathogenic mechanism in the genesis of lymphomas and PC malignancies is the deregulation of proto-oncogenes (e.g., MYC, BCL2, BCL6) and the inactivation of tumor suppressor genes (e.g., PRDM1) that have crucial functions in the control of normal B-cell and PC development through genetic aberrations [6]. The gene discussed is BCL6; the disease is pachyonychia congenita.