For example, LTA (lymphotoxin alpha) has been proved to be highly related with non-Hodgkin lymphoma; for ANXA1 (annexin A1), the loss of function or expression of this gene has been detected in multiple tumors; and the gene product of SPARC has been correlated with metastasis based on changes to cell shape that can promote tumor cell invasion. The gene discussed is SPARC; the disease is neoplasm.