For example, LTA (lymphotoxin alpha) has been proved to be highly related with non-Hodgkin lymphoma; for ANXA1 (annexin A1), the loss of function or expression of this gene has been detected in multiple tumors; and the gene product of SPARC has been correlated with metastasis based on changes to cell shape that can promote tumor cell invasion. This evidence concerns the gene LTA and neoplasm.