AKT1 and neoplasm: In conclusion, regardless of whether SIRT1 has a pro-survival role by repressing TSGs, upregulating the expression of oncogenes, and activating oncogeneic signaling pathways such as PI3K/Akt and Ras-MAP kinase, or whether it has a proapoptotic role by reducing tumorigenesis and AR-mediated proliferation, downregulating the expression of oncogenes, and participating in ER-α-mediated signaling pathways and the EMT process, there is no doubt as to its significant role in breast carcinogenesis.