SIRT1 and breast neoplasm: Actually, SIRT1 overexpression in breast tumors and mammary BC cell lines is significantly associated with lymph node metastasis, advanced TNM stage, low grade as per the modified Bloom–Richardson system, lymphovascular invasion, shorter disease-free survival (DFS), and overall survival (OS), luminal subtype, ER and PR expression, and is marginally associated with p53 loss [54,55,56].