For example, SNORD113-1 is significantly downregulated in HCC-tumour tissues compared with non-tumour tissues; furthermore, a statistically significant association between low-level expression of SNORD113-1 and relapse-free survival was observed, which suggests that downregulation of SNORD113-1 is associated with HCC aggressiveness [84]. The gene discussed is SNORD113-1; the disease is hepatocellular carcinoma.