PWAR5 and hepatocellular carcinoma: In another study conducted by Zhang et al. in 2016 [71], lncRNA hypoxia-inducing factor a (aHIF), Prader Willi/Angelman region RNA 5 (PAR5), and human downregulated expression by HBx (hDREH) were associated with HCV-related HCC since their expressions were significantly downregulated (aHIF and PAR5) or upregulated (hDREH) in tumour vs. non-tumour tissues, but these observations have to be confirmed in a larger patient cohort.