ATP2A1 and Brody myopathy: Similarly, mutations in the gene ATP2A1 (sarco(endo)plasmic reticulum calcium-ATPase 1 (SERCA1)) on chromosome 16p11 result in Brody myopathy, which is characterized by a decrease or loss of sarcoplasmic reticulum Ca2+-ATPase activity and problems with muscle contraction [13].