In the example of APL, a reciprocal translocation is acquired on the RAR gene on chromosome 17, and, in most of the cases, on the PML gene located on chromosome 15 or more rarely on the promyelotic leukemia zinc finger (PLZF) gene located on chromosome 11 resulting in a PML-RARα or PLZF-RARα fusion protein. Here, PML is linked to acute promyelocytic leukemia.