Furthermore, TTP depletion increased the production of several chemokines, such as C-X-C motif chemokine ligand 1 (CXCL1), CXCL2, and CXCL8 (also known as IL-8), which are involved in melanoma pathogenesis and angiogenesis [32,33,95]. The gene discussed is CXCL1; the disease is melanoma.