For example, we integrated 420 cancer mutations from TCGA (42) for a human PIKK family kinase, MTOR (Figure 4), which is frequently mutated in a variety of cancers, especially uterine corpus endometrial carcinoma (UCEC) and colon adenocarcinoma (COAD) (Figure 4, Supplementary Figure S3A) (45). Here, MTOR is linked to cancer.