MiR-375 has been reported to inhibit diabetes by targeting the expression of mRNA targets of miR-375 such as Gephyrin (GPHN), Insulin induced gene 2 (INSIG2), Myotrophin (MTPN) and Eukaryotic translation elongation factor 1 (Eef1e1) [57]. Here, INSIG2 is linked to diabetes mellitus.