Extracellular domain structure can be tumor necrosis factor—invertase (conventional) pyrolysis and then directly with shift growth factor beta (TGF—beta) and inhibition of TGF—beta signaling, thus we speculated that VASN may be mediator between tumor progression and angiogenesis, and it also can promote cancer cell proliferation and migration, which is a transmembrane protein VASN regulating tumor metastasis through the new way. This evidence concerns the gene TNF and cancer.