In never users, however, the variants were statistically significantly associated with CRC risk, and their effect sizes were strengthened (LEP rs2167270: OR = 1.54, 95% CI: 1.19–1.99, pFDR = 0.003; LEP rs4731426: OR = 1.37, 95% CI: 1.08–1.74, pFDR = 0.03) (pFDR for interaction: 0.02 and 0.02, respectively). This evidence concerns the gene LEP and colorectal carcinoma.