Consistent with these observations, the CRC risk conferred by LEP variants rs2167270 and rs4731426 was highest among women who fulfilled all three categories of low estrogen exposure: non-obese, post-menopausal, never users of EO HRT (LEP rs2167270: OR = 1.69, 95% CI: 1.26–2.26, pFDR = 0.003; LEP rs4731426: OR = 1.49, 95% CI: 1.13–1.96, pFDR = 0.003). The gene discussed is LEP; the disease is colorectal carcinoma.