SLFN12 and experimental autoimmune encephalomyelitis: Experimental evidence shows that Slfn8 knockout mice have lower expression of pro-inflammatory cytokines and are resistant to induced experimental autoimmune encephalomyelitis (EAE), the mouse model of MS.[28] Though Slfn8 is a different member of the Schlafen family, its clear role in EAE makes SLFN12 an appealing target for further research in MS.