Though not in the list of 200 definite MS-associated SNPs, variants in NINJ2 have been identified as “suggestive” MS-associated SNPs.[6] The increased methylation in this gene in CD4+ T cells from MS cases could be due to NINJ2 variants, to an environmental factor, or to both, possibly acting in concert within an individual. The gene discussed is CD4; the disease is myeloid sarcoma.