RDH5 and metabolic dysfunction-associated steatotic liver disease: [7] In NAFLD, disturbances of hepatic gene expression have been reported, [28,35] among them an increased expression of AKR1B10 [17,18] and other genes involved in retinoid-metabolism (ADH1A, ADH1B, ADH1C, RDH5, RDH10, RDH11, DHRS3, ALDH1A1, and ALDH1A3) whereas MYC (v-myc avian myelocytomatosis viral oncogene homolog) was under-expressed.