AKR1B1 and hepatocellular carcinoma: As AKR1B10 shares 70% sequence identity with aldose reductase (AKR1B1), it would be interesting to assess the role of AKR1B1 in retinoids metabolism in NAFLD patients.[15] AKR1B1 has been implicated in the development of diabetic complications and might play a role in the glucido-lipidic metabolism and adipose tissue homeostasis.[49] Furthermore, animal models could be used to establish the role of AKR1B10 overexpression in connection with an altered retinoid metabolism in the progression of NAFLD to HCC.