As AKR1B10 shares 70% sequence identity with aldose reductase (AKR1B1), it would be interesting to assess the role of AKR1B1 in retinoids metabolism in NAFLD patients.[15] AKR1B1 has been implicated in the development of diabetic complications and might play a role in the glucido-lipidic metabolism and adipose tissue homeostasis.[49] Furthermore, animal models could be used to establish the role of AKR1B10 overexpression in connection with an altered retinoid metabolism in the progression of NAFLD to HCC. Here, AKR1B1 is linked to metabolic dysfunction-associated steatotic liver disease.