Promoting or impairing IL-4Rα-mediated signaling yielded a similar result of Foxp3+ Treg cell impairment, therefore strongly arguing against the benefits of uninformedly modulating this cytokine receptor on Foxp3+ Treg cells to ameliorate tolerance, particularly in the current global context where helminthiasis are highly common. The gene discussed is FOXP3; the disease is helminthiasis.