To further elucidate the pathophysiology of adiponectin inpatients with established CAD, we investigated the association of adiponectin withvirtual histology intravascular ultrasound (VH-IVUS)-derived measures of degree andcomposition of coronary atherosclerosis, and with major adverse cardiac events(MACE), in patients undergoing coronary angiography. The gene discussed is ADIPOQ; the disease is coronary atherosclerosis.