Variations in amino acid residues at specific positions may influence the antigen‐presenting process and facilitate tumor cell evasion of host immune surveillance.16 Recently, a GWAS study fine‐mapped the HLA class I genes and detected several functional amino acids variants in the HLA‐A, HLA‐B, and HLA‐C loci.14 In addition, another GWAS study in Malaysian Chinese used high‐resolution fine‐mapping on HLA‐A and identified some variants in the antigen peptide‐binding groove and T‐cell receptor binding site.13 Here, HLA-A is linked to neoplasm.