For the amino acids in HLA class II genes, we discovered twelve amino acid polymorphisms in HLA‐DRB1 and HLA‐DQB1 associated with NPC susceptibility (Table S5), led by HLA‐DQB1 Glu‐45 (OR = 0.62, P = 6.58 × 10−11). The gene discussed is HLA-DQB1; the disease is nasopharyngeal carcinoma.