Two NPC protective haplotypes, HLA‐A*11—HLA‐B*13—HLA‐DQB1*03 and HLA‐A*11:01—HLA‐B*13:01—HLA‐DQB1*03:01 showed significance with Ptrend < 10−20. This evidence concerns the gene HLA-A and nasopharyngeal carcinoma.