Individuals carrying HLA‐A Gln‐62 (OR = 0.57, P = 1.41 × 10−16), the rs2894207G allele (OR = 0.52, P = 2.23 × 10−13), HLA‐DRB1 Phe‐67 (OR = 0.64, P = 9.64 × 10−11), or HLA‐B Glu‐45 (OR = 0.64, P = 5.23 × 10−8) showed lower NPC risk compared with those carrying the reference alleles. Here, HLA-DRB1 is linked to nasopharyngeal carcinoma.