We next applied colony formation assay in liver neoplasm cells and it came out to be a significant down‐regulation on cell proliferation ability in miR‐198 mimics group (P < 0.01), while that of cells from miR‐198 inhibitor group and pcDNA‐MYC group was strengthened (P < 0.01). The gene discussed is MYC; the disease is Neoplasm of the liver.