This enhanced IL‐1β secretion might account for the aggravation of inflammation.35 While in a report on LPS‐induced acute lung injury, ERS can activate NF‐κB,36 then it can promote kinds of cytokines’ secretion, such as IL‐6, IL‐23, IL‐17A, KC and G‐CSF. Here, CALCA is linked to acute lung injury.