However, excessive UPR may trigger inflammatory responses.30 A previous study has found the concurrence of herpes virus infection and UPR in the alveolar epithelial cells of patients with IPF, suggesting that virus infection may contribute to alveolar epithelial injury by exacerbating ERS.15 The current study found that compared with the mice treated with BLM+Saline, the mice treated with BLM+HSV1 demonstrated significantly elevated expression of UPR‐related proteins and particularly higher CHOP expression in lung tissue. Here, DDIT3 is linked to idiopathic pulmonary fibrosis.