The same set of genes was found significantly upregulated in the DLPFC of the subgroup of MDD patients with psychotic characteristics compared to control subjects: HDAC4, HDAC5, HDAC6, HDAC8, and DNMT3B (by 83, 46, 83, 66, and 40%, respectively; p < 0.05). This evidence concerns the gene DNMT3B and major depressive disorder.