NFKB1 and amyotrophic lateral sclerosis: CCL1 is secreted by the monocytes or macrophages in response to LPS exposure to promote the NF-κB pathway, and CXCL1 is also implicated in NF-κB activation through the PI3K/AKT signaling pathway and is also increased in ALS patient’s fibroblasts [35, 36].