HNF1A and type 2 diabetes mellitus: The effect of sodium-glucose transporter-2 inhibitor agents in HNF1A-MODY, who already have decreased expression of SGLT2 and low renal threshold, was shown in a single dose study to induce greater glycosuria than in type 2 diabetes [80] and it is unknown whether this would lead to greater adverse effects or increased efficacy of the agents.