NR3C1 and post-traumatic stress disorder: For example, at least a subpopulation of PTSD patients show increased sensitivity of the negative-feedback system of the HPA-axis and lower cortisol levels (Yehuda 2002), while (systemic or intra-BLA) administration of GR agonists promotes extinction in rodents (Flores et al. 2018) and in humans with PTSD or other anxiety disorders (de Quervain et al. 2011; Michopoulos et al. 2017; Soravia et al. 2014).