Most notably, upon transplantation into chick embryos, KC‐NC migrated along stereotypical pathways and gave rise to multiple NC derivatives, providing strong support of their NC phenotype.17 Given the accessibility of human skin and the high proliferation capacity of KC and KC‐NC, these cells represent a potentially useful source of multipotent stem cells for treatment of demyelinating diseases or spinal cord injuries. Here, CALCA is linked to demyelinating disease.