UCA1 and neoplasm: In order to investigate whether UCA1-containing exosomes could be a useful tumor-derived material for predicting the clinical outcome of cetuximab therapy in CRC patients, we used qRT-PCR to evaluate the features of UCA1-containing exosomes in the peripheral blood from 53 patients who were treated with cetuximab in combination with chemotherapy either as first-line (n = 39, 73.6%) or third-line therapy (n = 14, 26.4%).