In this study, we firstly investigated the association of serum FST levels with patients in two broad histological subtypes of lung cancers: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), and NSCLC was subdivided into lung adenocarcinoma (LADC), squamous cell carcinoma (SCC), lung adenosquamous cell carcinoma (LASC) and large cell lung cancer (LCLC). Here, FST is linked to lung large cell carcinoma.