We have previously reported that tumour-infiltrating lymphocytes (TILs) can be reliably and successfully isolated from pancreatic cancer lesions and expanded in vitro using a cocktail of IL-2, IL-15 and IL-21.16 In the present study, we characterised the neoepitope recognition profile of TILs as well as peripheral blood T cells from patients with pancreatic cancer. Here, IL15 is linked to familial pancreatic carcinoma.