HLA-B and familial pancreatic carcinoma: This is of note, since BRCA1 mutations are implicated as a key contributing factor related to the burden of somatic mutations in pancreatic cancer.25 We also found seven-point mutations in the HLA-A alleles, two-point mutations in the HLA-B alleles and eight-point mutations in the HLA-C alleles, which ultimately gave rise to amino acid changes in the resulting protein products associated with the HLA class I antigen processing and presentation pathway (Supplementary Table 2).