AKT1 and neoplasm: Immunologically, dying tumour cells release an excess of potassium into the tumour microenvironment, which has a deleterious effect on infiltrating T cells by impairing the TCR-Akt-mTOR signalling cascade for effector functions, including IFN-γ production.56,57 Thus, the effect of induction of cell death as well as specific immune-suppressive activity in the tumour microenvironment and how they influence adoptive T-cell therapies warrant consideration in developing cellular therapies.