In particular, Ang2 inhibition reduced the number of intra-tumoural Tie-2+monocytes, thereby increasing the efficacy of anti-angiogenic drugs12 leading to efficient blockade of angiogenesis, tumour growth and metastasis.13 While the above-mentioned observations refer to experimental cancer models, a number of investigations in colorectal cancer patients concerning the prognostic relevance of immune cell infiltration remained contradictory.14–16 Notably, none of these studies stratified for patients who received anti-angiogenic therapy. Here, ANGPT2 is linked to colorectal cancer.