Differently from IL-38, IL-36Ra, and IL-36γ were upregulated in the epidermis of Hidradenitis suppurativa (HS), Sweet Syndrome (SS), Pyoderma Gangrenosum (PG), and Atopic Dermatitis (AD), as compared with healthy skin, with different localization among disorders. This evidence concerns the gene IL36RN and pyoderma gangrenosum.