Differently from IL-38, IL-36Ra, and IL-36γ were upregulated in the epidermis of Hidradenitis suppurativa (HS), Sweet Syndrome (SS), Pyoderma Gangrenosum (PG), and Atopic Dermatitis (AD), as compared with healthy skin, with different localization among disorders. The gene discussed is IL36RN; the disease is hidradenitis suppurativa.