Differently from IL-38, IL-36Ra, and IL-36γ were upregulated in the epidermis of Hidradenitis suppurativa (HS), Sweet Syndrome (SS), Pyoderma Gangrenosum (PG), and Atopic Dermatitis (AD), as compared with healthy skin, with different localization among disorders. Here, IL36RN is linked to histiocytic sarcoma.