However, mice infected with ORF46.CM exhibited robust splenomegaly (Fig. 3A), established latency (Fig. 3B and Table 2), and reactivated from latency (Fig. 3C and Table 1) at levels indistinguishable from those of mice infected with ORF46.CM MR. The gene discussed is NR3C2; the disease is Splenomegaly.