HAVCR2 and rheumatoid arthritis: Several studies have demonstrated that TIM-3 polymorphism could be associated with ADs, such as multiple sclerosis (MS), Graves’ disease (GD), Hashimoto’s disease (HD), autoimmune thyroid diseases (AITDs), ankylosing spondylitis (AS), idiopathic thrombocytopenic purpura (ITP), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) [21–32].