ADIPOQ and rheumatoid arthritis: Frommer et al. showed the differential effects of adiponectin isoforms on effector cells involved in RA pathophysiology: HMW/MMW-enriched and globular adiponectin strongly activated expression of chemokines and pro-inflammatory cytokines in RA synovial fibroblasts (RASFs), while the adiponectin trimer (LMW) led to minimal chemokine and cytokine expression [22].