We recently suggested that adiponectin may contribute to synovitis and joint destruction in RA by stimulating the expression of vascular endothelial growth factor (VEGF) and MMP-1 and MMP-13 in fibroblast-like synoviocytes (FLSs) to a greater extent than do pro-inflammatory mediators [14]. Here, ADIPOQ is linked to rheumatoid arthritis.