MR activation leads to inflammation and oxidative stress, which in turn lead to vasoconstriction in the acute phase [24] and to tissue fibrosis in the case of sustained chronic activation [24] (i.e., tubulo-interstitial fibrosis in the kidney, cardiac fibrosis in chronic heart failure, arteriosclerosis in the vascular bed). The gene discussed is NR3C2; the disease is arteriosclerosis disorder.