In immunofluorescence studies, regenerating FD antlers obtained from an independent herd showed UHRF1 expression in RM tissue (Fig. 5a) while supplementation of known mitogens such as fibroblast growth factor-2 (FGF-2) and insulin-like growth factor-1 (IGF-1) in RM cells showed a good correlation between UHRF1 expression and RM cell proliferation (Additional file 1: Figure S4). Here, FGF2 is linked to Fabry disease.