Treatment with the ERβ-agonist DPN was associated with improved cardiac hemodynamics, as the RPP and LVDP of mice in the DPN-treated group were significantly improved to 62,261 ± 5963 from 33,530 ± 2663 for the RPP and to 124.2 ± 7.1 from 86.2 ± 2.7 for the LVDP versus HF, while PPT treatment had no effect on LV mechanical performance as the RPP (40,666 ± 2020) and LVDP (101.9 ± 8.0) were not significantly different from HF (Fig. 6a, Table 1). This evidence concerns the gene ESR2 and hydrops fetalis.