Recent reports demonstrate that lncRNAs play an important role of epigenetic gene regulation in GBM, for example, NEAT1 caused of ICAT, GSK3B and Axin2 genes silencing through interacting with EZH2 and mediating H3K27me3 increase, and promoted GBM cell growth and invasion, and then contributed to GBM progression [10]. The gene discussed is CTNNBIP1; the disease is glioblastoma.