In summary, our current work revealed that the GBM-associated lncRNA HOTAIRM1 was an oncogenic factor that regulated HOXA1 gene expression, promoting tumorigenesis by serving as a scaffold to sequester the chromosome modification enzyme G9a, EZH2 and DNA methyltransrase Dnmts away from the promoter of HOXA1 gene. Here, HOTAIRM1 is linked to glioblastoma.