HOXA1, one of the HOXA gene cluster members, has been found to be up-regulated in human malignancies, such as non-small cell lung cancer [30], oral squamous cell carcinoma [31], uterine leiomyosarcoma [32] and breast cancer [33–35], and function as an oncogene. This evidence concerns the gene HOXA1 and oral cavity squamous cell carcinoma.