For example, ipilimumab is a humanized IgG1 recombinant antibody that can mediate antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cellular cytotoxicity, and may deplete tumor-infiltrating Tregs, which have elevated expression of CTLA-4 compared with Teff cells [52, 53]. The gene discussed is CTLA4; the disease is neoplasm.