In multivariable regression models, the associations between antibody responses and clinical malaria remained statistically significant after correction for multiple comparisons for anti-C-term CSP IgG2 levels, M3–M0 changes in IgG and IgG1, and cytophilic to non-cytophilic IgG subclass ratio, as well as anti-HBsAg levels (IgG, IgG1, IgG3) and subclass ratio (Table 2). The gene discussed is IGHG3; the disease is malaria.