Furthermore, our data support that the balance of anti-CSP IgG subclasses more than the total IgG levels is important for protection against clinical malaria, as a higher ratio of cytophilic IgG1 and IgG3 to non-cytophilic IgG2 and IgG4 antibodies was associated with antimalarial immunity. This evidence concerns the gene IGHG3 and malaria.