Chen et al considered that CYR61 may suppress HCC through both apoptotic and growth inhibitory mechanisms to prevent tumor progression during the very early stages of oncogenesis; one such example is suppression of hepatocarcinogenesis by inhibiting compensatory EGFR-dependent hepatocyte proliferation through integrin α6-ROS-p38 MAPK-mediated activation of p53 [38]. This evidence concerns the gene EGFR and hepatocellular carcinoma.